The major goal of this research was to design and test floating tablets employing sodium bicarbonate and HPMC, aimed at increasing stomach residence duration for enhanced medication bioavailability and physicochemical compliances. The manufactured tablets passed compliance norms for several physicochemical parameters, including dimensions, floating time, tablet density and drug content. The method of Formulations for batches F2, F5 and F6 showed favourable drug release profiles, with the F7 formulation demonstrating exceptional release characteristics. The drug release kinetics studies revealed that the F2, F5, F6 and F7 formulations followed the Korsmeyer-Peppas model, indicating non-fickian diffusion with 'n' values ranging from 0.521 to 0.633. The stability studies revealed that the formulations F2, F5, F6 and F7 demonstrated stability at room temperature, 40°C and 2-8°C for 30 days, with refrigerated storage maintaining stability for 60 days. In conclusion, the produced hydrodynamically balanced Moxifloxacin HCl tablets have promising physicochemical properties, dissolving profiles and stability. These tablets have the potential to increase medication bioavailability, making them a viable choice for targeted drug delivery in the upper gastrointestinal tract.
Loading....